Tag: ovarian cancer – talcum powder

FDA Approves New Ovarian Cancer Drug

The Talcum Powder Lawsuit Helpline has qualified Baby Powder and Shower To Shower lawyers for women who feel their ovarian cancer diagnosis is due to ” dusting Off ” for years with talcum powder products.  The Talcum Powder Lawsuit Helpline continues to keep woman and families updated on the talcum Powder Lawsuit latest news and any new research or news pertaining to ovarian cancer that we think will be helpful to our readers.

We found this  online and feel it is important information for our readers.

FRIDAY, Dec. 19, 2014 (HealthDay News) — The U.S. Food and Drug Administration has approved a new drug to treat advanced ovarian cancer, along with a test to identify patients eligible to receive the drug.

Lynparza (olaparib) belongs to a new class of drugs called poly ADP-ribose polymerase (PARP) inhibitors. The drug is for women who have already received extensive treatment for advanced ovarian cancer associated with defective BRCA genes, according to an FDA news release issued Friday.

“Today’s approval constitutes the first of a new class of drugs for treating ovarian cancer,” Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research, said in the news release.

“Lynparza is approved for patients with specific abnormalities in the BRCA gene and is an example of how a greater understanding of the underlying mechanisms of disease can lead to targeted, more personalized treatment,” he said.

Approval of the AstraZeneca drug was based on a clinical trial of almost 140 women with BRCA mutation-associated ovarian cancer. Thirty-four percent of the patients on the drug had partial shrinkage or complete disappearance of their tumors for an average of eight months, the FDA reported.

Nausea, fatigue, vomiting, diarrhea, headache, decreased appetite, joint and muscle pain, and cold-like symptoms were common side effects of the drug. More serious side effects included lung inflammation; the bone marrow cancer acute myeloid leukemia; and myelodysplastic syndrome, a condition where the bone marrow is unable to produce enough functioning blood cells, the FDA said.

Women must undergo a genetic test to confirm BRCA gene mutations before they can be treated with Lynparza. The test to confirm those genes was approved by the FDA in conjunction with the drug.

BRCA genes play a role in repairing damaged DNA. Normally, they work to suppress tumor growth. Women with mutations that cause defective BRCA genes have an increased risk for ovarian and breast cancer. It’s believed that 10 to 15 percent of all ovarian cancer is associated with these mutations, the FDA said.

In 2014, nearly 22,000 American women will be diagnosed with ovarian cancer and more than 14,000 will die from the disease, according to the U.S. National Cancer Institute.

If you or a loved one has a diagnosis of ovarian cancer and has used talcum powder products for years contact the Talcum Powder Lawsuit Helpline.

Liquid Biopsies For Earlier Ovarian Cancer Tracking

The Talcum Powder Lawsuit Helpline continues in one of  it’s missions  to offer the latest news regarding ovarian cancer. We receive dozens of calls on a daily basis from women who feel their use of Talcum Powder products has resulted in their ovarian cancer diagnosis. We continue to connect women with qualified talcum powder ovarian cancer lawyers and offer news we feel will be helpful to these women.

We found this latest news online and hope it will be helpful to our followers.

There is new news about  liquid biopsies offering  hope for earlier treatment and  better tracking of ovarian cancer.

A promising new way to monitor and treat recurrence of ovarian cancer has been identified by researchers a hard-to-detect disease that claims many lives. New research finds liquid biopsies from blood tests and DNA sequencing can detect a return of ovarian cancer long before a tumor reappears.

If you have used Talcum Powder products and suspect an ovarian cancer this may be an option to check out with your doctor.

Researchers at the Mayo Clinic Center for Individualized Medicine have found a promising new way to monitor and treat recurrence of ovarian cancer — a hard-to-detect disease that claims many lives. New research from George Vasmatzis, Ph.D., of the Department of Laboratory Medicine and Pathology at Mayo Clinic, finds liquid biopsies from blood tests and DNA sequencing can detect a return of ovarian cancer long before a tumor reappears. That could lead to earlier intervention and more effective, individualized treatment. Dr. Vasmatzis’ research on the “Quantification of Somatic Chromosomal Rearrangements in Circulating Cell-free DNA From Ovarian Cancers” is published in the July 20 edition of Scientific Reports.

“With liquid biopsies, we don’t have to wait for tumor growth to get a DNA sample,” says Dr. Vasmatzis. “This important discovery makes it possible for us detect recurrence of the disease earlier than other diagnostic methods. We can repeat liquid biopsies to monitor the progression of the cancer. That gives hope of a better treatment plan over time.”

The study was done on 10 patients in advanced stages of ovarian cancer. Blood was drawn before and after surgery. Investigators compared DNA from the liquid blood biopsies to DNA tissue samples from the tumor, using mate-pair sequencing — an inexpensive whole exome sequencing that can reveal genetic changes that contribute to tumor growth.

“In this study, the blood drawn before and after surgery and the surgical tissue was used to identify DNA fragments with abnormal junctions that can only be seen in this patient’s tumor DNA,” explains Dr. Vasmatzis. “Next-generation mate-pair sequencing was used to identify specific DNA changes of the tumor to create an individualized monitoring panel for liquid biopsy. This allows us to shape treatment to the individual patient rather than using a standard treatment that may not work for everyone.”

When post-surgery DNA matched that of the tumor, patients were later found to have had a recurrence of ovarian cancer. However, when the post-surgery DNA did not match the DNA of the tumor, patients were found to be in remission.

Ovarian cancer has one of the highest death rates of all gynecological cancers, because the tumor often cannot be detected until the late stages. Most patients go into remission after initial treatment, but the tumor returns 75 percent of the time. The next stage of ovarian cancer that develops typically does not respond to chemotherapy. More than 21,000 women in the U.S. were diagnosed with ovarian cancer, and 14,000 women died of the disease in 2015.

We wonder if the 1000’s of women using talcum powder products and the latest research on the link between talcum powder use and ovarian cancer has anything to do with such huge numbers. Many women have used talcum powder for years, especially in the Afro American and Hispanic community. J & J marketed their products to these women and the idea of smelling fresh and clean became a girlfriend to girlfriend positive  in smelling  “sweet and fresh like  Talcum Powder today.”

Symptoms of Ovarian Cancer

Symptoms of Ovarian Cancer

Symptoms of very early ovarian cancer
The stage of a cancer describes how far it has grown and spread. Very early stage cancer means cancer that is completely inside the ovary and is also called stage 1.

Many women with a very early stage of ovarian cancer don’t have any symptoms. If they do have symptoms, they may be vague and can include

Pain in the lower abdomen or side
Bloated, full feeling in the abdomen
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 Symptoms if the cancer has grown outside the ovary
Cancer that has grown outside the ovary includes stage 2 and stage 3 ovarian cancer.

These may cause symptoms from the tumour growing anywhere in the area between the hip bones (the pelvis) such as

Irregular periods or vaginal bleeding after menopause
Lower tummy (abdominal) pain
Back pain
Passing urine more often than usual
Constipation
Pain during sex
A swollen abdomen
Feeling of fullness or loss of appetite
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Symptoms of ovarian cancer that has spread
Doctors call cancer that has spread to a distant body organ, such as the lungs, stage 4 ovarian cancer.  Symptoms may include

Loss of appetite or a feeling of fullness in the abdomen
Feeling or being sick
Constipation
Tiredness
Shortness of breath
Noticeable swelling of the abdomen